Poliomyelitis Vaccine (Vero Cell), Inactivated, Sabin Strains (sIPV) is independently developed by BIBP and has independent intellectual property rights. This product is a trivalent liquid vaccine prepared by inoculating Vero cells with Type I, II and III attenuated Sabin strains respectively, cultivating and harvesting virus solution, concentrating, purifying, inactivating, and then mixing in proportion.

In 2016, BIBP was the first company to market Poliomyelitis (Live) Vaccine Type I Type III (Human Diploid Cell), Oral (bOPV) in China. The product is a bivalent liquid vaccine prepared by inoculating human diploid cell 2BS strain with poliovirus type I and III attenuated strains respectively, cultivating and harvesting the virus solution, and is applicable to the prevention of poliomyelitis.

Measles, Mumps and Rubella Combined Vaccine, Live (MMR) is prepared by inoculating primary chicken embryo cells with attenuated strain of measles virus Hu-191 and attenuated strain of mumps virus S79 respectively, and inoculating human diploid cells with attenuated strain of rubella virus BRD Ⅱ, cultivating and harvesting the virus solution, mixing and preparing in proportion, adding appropriately diluted stabilizer and then lyophilizing.

Measles and Rubella Combined Vaccine, Live (MR) is prepared by inoculating primary chicken embryo cells with attenuated strain of measles virus Hu-191, and inoculating human diploid cells with attenuated strain of rubella virus BRD Ⅱ, cultivating and harvesting the virus solution, mixing and preparing in proportion, adding appropriately diluted stabilizer and then lyophilizing.

Yellow Fever Vaccine (Live) is produced with the attenuated strain of yellow fever virus 17D. For Yellow Fever Vaccine (Live) produced by BIBP, the preparation process of bulk includes: inoculating 7-8 day-old SPF eggs with appropriately diluted working seeds, culturing at 37°C after inoculation, harvesting qualified single harvests, grinding and centrifuging. The preparation process of final bulk includes: adding stabilizer in a certain proportion according to the virus titer of the bulk to dilute the bulk to the virus titer of 6.0lgPFU/ml, sterilizing and filtering. The final product can be obtained by filling, lyophilizing and packaging the final bulk.

This product is manufactured fromBordetella pertussis,Diphtheria bacillus andClostridium tetani through the fermentation, purification, detoxification and other processes to obtain acellular pertussis vaccine bulk, diphtheria bulk and tetanus bulk respectively, and then the addition of aluminum hydroxide adjuvant. It contains aluminum hydroxide, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium merthiolate and other excipients, but no antibiotics.

This product is manufactured from neisseria meningitidis serogroups A, C, Y and W135 inoculated in modified semi-composite liquid media through culturing, harvesting, sterilization, purification, separate extraction of neisseria meningitidis serogroups A, C, Y and W135 capsular polysaccharide antigens, mixing, addition of appropriate amount of lactose and lyophilization. It contains neisseria meningitidis serogroups A, C, Y and W135 capsular polysaccharide antigens, sterile water for injection and lactose, but no antibiotics.

In 1995, BIBP introduced the Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) (rHBV) technology from Merck, and obtained the marketing approval for rHBV. It is produced by hepatitis B virus surface antigen (HBsAg) expressing in Saccharomyces cerevisiae. The culture is purified by cell breakage, cell debris removal, small molecules removal, gel adsorption, boric acid elution, ultrafiltration, concentration and hydrophobic chromatography, and then perform the in-situ adsorption, and dilute by adding aluminum adjuvant to prepare the vaccine. It is semi-transparent suspension which displays a slightly white to off-white color after shaking, could be layered by precipitation, and the precipitation can be easily dispersed by shaking. It is free of preservatives, and can be used for prevention of hepatitis B.